Treatment of uncomplicated gonorrhoea with spectinomycin hydrochloride (Trobicin).
نویسندگان
چکیده
110 patients with uncomplicated gonococcal urethritis were treated with 2 g spectinomycin (Trobicin) intramuscularly. Seventy-five patients were available for follow-up and there was only one treatment failure, giving a cure rate of 98-6%. Of the 99 gonococcal isolates, 59 were sensitive to 5 microng/ml of spectinomycin or less and 40 were sensitive to 10 microng/ml. In a small sample of patients 2 g spectinomycin intramuscularly produced a serum concentration averaging 100 microng/ml after one hour.
منابع مشابه
Spectinomycin hydrochloride in the treatment of uncomplicated gonorrhoea in males and females.
Penicillin is still the drug of choice in the treatment of gonorrhoea in most countries, but its use is becoming increasingly limited by the development of resistant strains of gonococci (Amies, 1967; Sparling, 1972; Hafermann, Cooper, and Chesney, 1973). Allergic reactions to penicillin are also a significant problem. About 3 to 5 per cent. of patients attending venereal disease clinics claim ...
متن کاملSpectinomycin hydrochloride in the treatment of uncomplicated gonorrhoea.
In 1960 spectinomycin, a new broad spectrum antibiotic, was released for clinical investigation and it was shown that the administration of 2 g. of the sulphate salt was effective therapy in acute gonorrhoea yielding cure rates of approximately 87 to 95 per cent. in males. The cure rate in females was 92 per cent. with a 3 g. dose (Laird and Taylor, 1962; Wilcox, 1963; Tiedemann, Hackney, and P...
متن کاملSpectinomycin hydrochloride (Trobicin) in the treatment of gonorrhoea. Observation of resistant strains of Neisseria gonorrhoeae.
Treatment of gonorrhoea with penicillin injections is still considered to be the method of choice, as penicillin is both non-toxic and highly effective when given in suitable doses. However, since about 5 per cent. of patients attending venereal disease clinics are allergic it is important to have several alternatives available. Various injectable antibiotics other than penicillin can be used, ...
متن کاملPreliminary report on spectinomycin HCl in the treatment of gonorrhoea in homosexual men.
Homosexuality plays an important role in the diagnosis, treatment, and epidemiology of venereal diseases. Jefferiss (1966) found that 89 (15 per cent.) of 604 males with gonorrhoea seen at St. Mary's Hospital in London admitted homosexual contact. Ekstr6m (1970) found that 12 per cent. of 100 males aged 14 to 19 years who reported for treatment of venereal disease in Copenhagen had engaged in h...
متن کاملSpectinomycin: minimum inhibitory concentrations for Neisseria gonorrhoeae.
Actinospectacin, a broad-spectrum antibiotic derived from Streptomyces spectabilis, was released for clinical trials more than 10 years ago. Although it possesses activity against many micro-organisms, both Gram-positive and Gram-negative, its use has been limited mainly to the treatment of gonorrhoea. Its efficacy in the treatment of this disease has been reported by a number of investigators....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The British journal of venereal diseases
دوره 53 2 شماره
صفحات -
تاریخ انتشار 1977